ABSTRACT
Two Schiff bases, namely benzoin thiosemicarbazone [BTSC] and para-anisaldehyde semicarbazone [PAS], were synthesized and characterized. The antineoplastic activities of these Schiff bases were studied against Ehrlich ascites carcinoma [EAC] cells in Swiss albino mice by monitoring tumor cell growth inhibition, tumor weight measurement, survival time of tumor-bearing mice, bioassay of these compounds, and counting the total number of peritoneal cells as well as macrophages. Hematological parameters were also studied. It was found that these compounds significantly reduced tumor cell growth rate, decreased tumor weight, and increased life span of EAC-bearing mice. These test compounds restored the hematological parameters of EAC-bearing mice to normal. These compounds also enhanced the number of macrophages in normal mice. The results obtained were compared with those obtained with the standard drug bleomycin
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the protective role of leaves of Moringa oleifera (M. oleifera) Lam. against arsenic-induced toxicity in mice.</p><p><b>METHODS</b>Swiss albino male mice were divided into four groups. The first group was used as non-treated control group while, the second, third, and fourth groups were treated with M. oleifera leaves (50 mg/kg body weight per day), sodium arsenite (10 mg/kg body weight per day) and sodium arsenite plus M. oleifera leaves, respectively. Serum indices related to cardiac, liver and renal functions were analyzed to evaluate the protective effect of Moringa leaves on arsenic-induced effects in mice.</p><p><b>RESULTS</b>It revealed that food supplementation of M. oleifera leaves abrogated the arsenic-induced elevation of triglyceride, glucose, urea and the activities of alkaline phospatase, aspartate aminotransferase and alanine aminotransferase in serum. M. oleifera leaves also prevented the arsenic-induced perturbation of serum butyryl cholinesterase activity, total cholesterol and high density lipoprotein cholesterol.</p><p><b>CONCLUSIONS</b>The results indicate that the leaves of M. oleifera may be useful in reducing the effects of arsenic-induced toxicity.</p>